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KMID : 0363320080290041000
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 4 p.1000 ~ p.1010
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The Effects of Evodiae fructus on Thyroid Function and Histological Modification in Hypothyroidism Rat Model Induced by PTU.
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Kang Chul-Ho
Song Moon-Koo
Kang Ji-Suck
Lee Byung-Cheol
Ahn Young-Min
Doo Ho-Kyung
Ahn Se-Young
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Abstract
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Objective: Hypothyroidism is a syndrome characterized by symptoms such as cold intolerance, or weight gain. Because of side effects of Western medicine treatment, interest in oriental medicine has been increasing. In this study, we examined the therapeutic effects of Evodiae fructus and histological modification in hypothyroidism rat model induced by PTU(6-propyl, 2-thiouracil).
Methods: After inducing hypothyroidism in the rats by PTU injections, we divided the rats into four groups, the Evodiae fructus 100 500, control, and LT₄(levothyroxine) groups. After 2 weeks Evodiae fructus and LT₄were administered, respectively. The weight was measured once a week. After sampling the blood for biochemical analysis to check the levels of T₃, T₄and TSH, the thyroid tissue was removed, stained with H&E, and an image was obtained using an optical microscope.
Results: Compared with normals, controls showed low T₄and high TSH. The Evodiae fructus group showed a statistically meaningful T₃increase to be dose related. But the levels of TSH showed no meaningful difference between the Evodiae fructus group and normals. About the biochemical tests(liver, kidney etc) and weight change, there was no meaningful difference between the Evodiae fructus group and controls. In the biopsy, the Evodiae fructus group showed thyroid tissue improvement compared to controls.
Conclusions: These results show that Evodiae fructus stimulates the decreased functions of the thyroid, and also has thyroid cell protecting effects. The lab results also showed that Evodiae fructus is a safe substance that doesn’t cause hepatotoxicity or nephrotoxicity. Therefore it is an effective substance in the treatment of hypothyroidism.
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KEYWORD
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Evodiae fructus, 6-Propyl, 2-thiouracil, Levothyroxine, Hypothyroidism
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